TSKgel ODS-80Ts is based on a high-purity, metalfree silica with 10 nm pore size bonded to C18 (ODS) groups resulting in an effective pore size of 8 nm (80 Å). It is completely endcapped to reduce ionic interactions. In addition, the silica does not contain metal ions or ammonium moieties that can broaden peaks of acidic compounds and chelating reagents.