TSKgel HIC-ADC Phenyl

TSKgel HIC-ADC Phenyl columns utilize a novel polymer-based resin functionalized with increased ligand densities targeted specifically for Antibody-Drug Conjugates (ADCs) and offer an alternate selectivity to TSKgel HIC-ADC Butyl columns. TSKgel HIC-ADC Phenyl columns are packed with 5.0 µm non-porous particles, enhancing the separation performance for calculating Drug-to-Antibody Ratios (DAR) for ADCs. Serves as an alternate selectivity option to TSKgel HIC-ADC Butyl suitable for antibody-oligonucleotide conjugates (AOCs) and various hydrophilic targets.

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P/N	Description	Particle Size (µm)	Housing Material	ID (mm)	Length (cm)	Price ($)
0023536	TSKgel HIC-ADC Phenyl	5	Stainless Steel	4.6	3.5	1,274	Inquire
0023537	TSKgel HIC-ADC Phenyl	5	Stainless Steel	4.6	10	1,488	Inquire

Product Attributes

Pore size (mean):	non-porous
Particle size (mean):	5 µm
pH stability:	2.0-12.0
Functional group:	phenyl

Separation performance of the TSKgel HIC-ADC Phenyl column in comparison to the HIC-ADC Butyl column

Columns:	TSKgel HIC-ADC Butyl, 5 μm and TSKgel HIC-ADC Phenyl, 5 μm both 4.6 mm ID × 10 cm
Mobile phase:	A: 0.1 mol/L Phosphate Buffer pH 7.0 + 1.0 mol/L Ammonium Sulfate B: 0.1 mol/L Phosphate Buffer pH 7.0 / Isopropanol (70/30, v/v)
Gradient:	0 min (0%B), 1 min (0%B) → 15 min (100%B)
Flow rate:	0.5 mL/min
Detection:	UV @ 215 nm
Temperature:	25 °C
Injection vol.:	20 μL
Sample:	0.5 mg/mL ADC Mimic (Sigma)

P/N	Description	Particle Size (µm)	Housing Material	ID (mm)	Length (cm)	Price ($)
0023542	TSKgel HIC-ADC Phenyl Guard Column	5	Stainless Steel	4.6	0.5	525

HPLC Columns

TSKgel HIC-ADC Phenyl

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Product Attributes

Separation performance of the TSKgel HIC-ADC Phenyl column in comparison to the HIC-ADC Butyl column