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LenS3 Multi-Angle Light Scattering Detector

The next generation of LenS™3 MALS detector provides the latest in light scattering detection from Tosoh Bioscience. Technological advancements in instrument design and software simplify exact molecular weight (MW) and radius of gyration (Rg) determinations of polymers and biomolecules.

Building upon the powerful and unique optical design of the original LenS3 MALS detector, the new generation features a lower cell volume, thus preserving chromatographic resolution even with U/HPLC systems and columns. The higher dynamic range increases the scope of MW determination from low to high scattering samples, further simplifying the analysis of small polymers and high molecular weight viral vectors alike.

Along with its technical hardware improvements and its wide screen control panel, the new LenS3 MALS detector is powered by SECview™ 3.1 software. This innovation to the user interface allows higher productivity with semi-automation and a streamlined workflow when processing multiple data files. Furthermore, a proprietary algorithm based on the theory of light scattering removes the historical guesswork of selecting an appropriate model for MALS calculations.

We’ve worked tirelessly in our labs developing our MALS solution to make sure your experience is hassle-free.

Introducing the new generation of LenS3 MALS detector and SECview software: light scattering made easy, for all.

LENS3G2 MALS
 
P/NDescriptionPrice
($)		 
0040100LenS3 Multi-Angle Light Scattering Detector-
0040000LenS3 Multi-Angle Light Scattering Detector-


Specifications

Light scattering
Number of measurement angles 3
Position of the measurement angles LALS (10°)   RALS (90°)   HALS (170°)
Cell geometry Patented dual conical flow path (single inlet, dual outlets)
Total cell volume 43 µL
Laser source type Diode
Laser power 1 - 50 mW (user-adjustable)
Laser wavelength 505 nm
Laser temperature control Peltier
Wetted material PTFE, PEEK, glass
Maximum flow rate 5 mL/min
Inlet position Side port (left)
Baseline noise (RMS without despiking) on RALS (90°) in THF @ 1 mL/min < 1 mV
Typical signal-to-noise ratio on RALS for 50 µg of PS 100KDa* 2000:1
MW range < 200 to 108 Da**
Rg range < 5 to > 250 nm**
Despiking level User-selectable (None, low, mid, high)



General
Acquistion rate 10 Hz
A/D board channels / resolution 8 channels / 24 bit
Dynamic range +/- 10 V
External analog inputs 2 auxiliary channels
Trigger input <= 12 V DC requiring dry contact closure
Trigger output Dry contact closure
Alert trigger output Dry contact closure
External USB hardware 2 USB A, 1 USB C (powered)
Onboard PC OS Windows 11 PRO
Onboard RAM / Storage 16 GB / 1 TB
Onboard processing SECview™ software
PC Connection Ethernet cat 5
Touch screen 13.3 in
Dimensions 46.0 (W) × 25.1 (H) × 58.5 (D) cm = 18.1” × 9.9” × 23”
Weight 19 kg / 42 lbs
Shipping weight 23 kg / 51 lbs
Operating environment 5 – 35 Celsius @ 10 to 80% relative humidity (no condensation)
Instrument voltage 100 – 240 V AC @ 50 / 60 Hz
Power requirements Typical 110 W, maximum 700 W
Intellectual property PCT/US19/12090: Light Scattering Detectors and Sample Cells for the Same
PCT/US19/12095: Light Scattering Detectors and Methods for the Same
WO 2023/038621 A1: Light Scattering Detectors and Methods for the Same


*: Narrow distribution, using 1 × 7.8 mm ID × 30 cm TSKgel GMHHR-M column
**: Depends on chromatographic separation and sample injected mass, conformation and refractive index increment (dn/dc)

Code #DescriptionLiterature Type
AN115 Analysis of Oligonucleotides by SECApplication Note
AN119 Characterization of Recombinant Protein Biotherapeutic using TSKgel UP-SW2000 Size Exclusion Chromatography Column In-Line with LenS3 MALS DetectorApplication Note
AN125 Molecular Weight Determination of VLPs Using LenS3 Multi-Angle Light Scattering DetectorApplication Note
AN126 Characterization of Biomacromolecules by FPLC coupled with the LenS3 MALS DetectorApplication Note
AN129 SEC-MALS of Antibody Therapeutics -- A Robust Method for In-Depth Sample CharacterizationApplication Note
AN133 Monitoring Structural Changes in Polysaccharides using SEC-MALSApplication Note
AN137 Trimeric SARS-COV-2 Spike Protein Analysis with SEC Coupled with MALSApplication Note
AN138 SEC-MALS Sensitively Quantifies Adeno-Associated Viruses and Detects ImpuritiesApplication Note
AN139 Analysis of PEGylated Antibody Fragments using SEC-MALSApplication Note
AN141 SEC-MALS Analysis Determines Molecular Weight and Oligomeric State of Membrane ProteinsApplication Note
AN145 Greener Solvent Alternatives in GPC/SEC and Light Scattering Analyses of PolymersApplication Note
AN147 Peptide Characterization: Native SEC and MALS for Accurate Molecular Weight DeterminationApplication Note
BR11 LenS3 MALS Detector: Multi-Angle Light Scattering made easy.Brochure
PD21 Increased Sensitivity with LenS3 MALS DetectorPerformance Data
PO55 Advanced Macromolecular Characterization made easyProduct Overview
TN001 Expanding the Boundaries of Light Scattering DetectionTechnical Note
TP229 Two-Step Purification Process for Mouse Monoclonal Antibody from Hybridoma Cell LineTechnical Presentation
WP001 Light Scattering for Determination of Molecular Weight and Radius of GyrationWhite Paper