Products
Multi Column Chromatography
The OctaveTM PRO is a GMP-ready multi-column chromatography (MCC) system for the purification of biopharmaceuticals at the clinical and commercial scale. The Octave PRO is designed for direct scale-up after process development on the Octave BIO, and both systems offer the same method-execution capabilities. The Octave PRO enables ultimate process versatility and agility to address the most challenging downstream bottlenecks.
- GMP-ready skid using reliable, patented Octave technology
- Specifically designed for typical clinical and commercial scale purification processes of 2000 L bioreactors within 1-2 shift times
- Flow rates ranging from 0.1 L/min to 2.5 L/min
- Up to eight columns
- Six pumps, six inlets, six outlets
- Single use flow path
- Integrated UV, conductivity, and pH sensors (4 of each)
- Complete data recording and analysis
- Includes PROComposer™ Method Creator and Method Wizard applications
- 21 CFR Part 11 compliant PROController™ control system
- Dedicated SkillPak PRO pre-packed columns for MCC applications are available
Specifications
System Architecture
| Description |
Specifications |
| Dimensions (W / D / H) |
213 / 115 / 219 cm, (198 cm without alarm tower) |
| Weight |
450 kg |
| Operating flow rate |
1 – 150 L/hr (2.5 L/min) |
| Maximum operating pressure |
6 bar (87 psi) |
| Valve Pressure |
8 bar (116 psi) |
| Gas inlet pressure |
9 bar (130 psi) |
| Column Positions/Connections |
1 to 8 columns, 3/4 in. sanitary clamps |
| Valve block |
1 single-use assembly containing 104 pneumatic two-way valves |
| Inlet number |
6 |
| Outlet number |
6 |
| Pumps |
6; 4-piston-diaphragm pump, flow rate ranges 1-150 L/h |
| Flowmeters |
6; 1 after each pump, flow rate ranges 0.01-8 L/min |
| Pressure sensors |
6; 1 after each pump, measuring range 1-10 bar |
| Outlet sensors |
4 assignable single-use combination UV/conductivity/pH |
| UV sensors |
UV 280 nm & 305 nm |
| Conductivity sensors |
CND range 0–850 mS/cm |
| pH sensors |
pH range 0-14 |
|
Single-Use Flowkit
| Item |
Description |
| Inlet Connections |
6 Aseptiquik® G |
| Outlet Connections |
6 Aseptiquik® G |
| Pumps |
6 Quattroflow® EZ-Set Pump Chamber quaternary diaphragm single-use heads |
| Pressure sensors |
6 single-use gauge tees (TS1, 1 after each pump) |
| Flow sensors |
6 single-use; ultrasonic (1 after each pump) |
|
Single-Use Materials of Construction
| Component |
Wetted Materials |
| Pump head |
Polypropylene (PP), thermoplastic elastomer (TPE), ethylene propylene diene monomer (EPDM) |
| Pressure adapter |
PP, TPE |
| Flow sensor |
PP |
| Valve block assembly |
USP class VI compliant polyetherimide (PEI), polyvinylidene fluoride (PVDF), polyfluoroalkoxy (PFA) |
| Optical/conductivity/pH flow cell |
Quartz (UV-transparent), EPDM, stainless steel 1.4435 (SS 316L), polyphenylsulfone (PPSU) |
| Fittings |
PEEK, platinum cured silicone, PP |
| Tubing |
1/4 in. ID polybraided platinum cured silicone, pump inlet is weldable 1/4 in. ID Advantaflex biopharmaceutical grade thermoplastic elastomer (TPE)
|
| Gamma irradiation dose |
25-40 kGy |
|
Electrical Requirements
| Parameter |
North America |
EMEA |
| Voltage |
120V;1 phase |
220-240V; 1 phase |
| Amps |
30A |
15A |
| Frequency |
60 Hz |
50 Hz |
| Number of Cords |
1 |
1 |
| Type of Plug |
NEMA L5-30P, with ground |
Must meet local code, with ground |
|