Multi Column Chromatography

Octave BIO MCC System

The Octave™ BIO  is the most comprehensive and versatile multi-column chromatography (MCC) system for process development and proof of concept. Leveraging established Octave MCC technology from other industries and tailoring it for bioprocess use cases, these systems are designed to intensify your existing biologic purification process. The unique modular design will fit your requirements and unlock the resin savings, buffer savings, and other tangible benefits that MCC can provide.

• Benchtop system based on rugged, reliable, patented Octave technology
• Specifically designed for bioseparations
• Flow rates ranging from 1 mL/min to 300 mL/min
• Up to eight columns
• Six pumps, six inlets, six outlets
• User-replaceable valve block available in three channel diameters
• Integrated UV, conductivity, and pH sensors (4 of each)
• Gradient capabilities and single column mode with sample injector
• Complete data recording and analysis
• Includes PROComposer™ Method Creator and Method Wizard applications
• Powerful, user-friendly, BIOController™ control system
• Dedicated SkillPak BIO pre-packed columns for MCC applications are available.


0041100Octave BIO MCC System-
Code #DescriptionLiterature Type
AN134 Protein L Chromatography Process Transfer for the Continuous Purification of Fab-FragmentsApplication Note
AN135 Two-Step Monoclonal Antibody Purification Using a Multi-Column Continuous Chromatography PlatformApplication Note
da0083a Octave™ BIO Specification SheetInstrument Specifications
PO51 Holistic Multi-Column Chromatography SolutionProduct Overview